缓释氟粘贴片体内防治龋齿效果的评价

Evaluating the anti-caries and remineralisation effects of a bioadhesive slow-release fluoride tablet in vivo

目的 评价缓释氟粘贴片体内防治龋齿的作用。方法 受试者 7例 ,无氟期 (唾液单独作用 )和有氟期 (唾液与氟片共同作用 )戴右侧上颌舌侧和左侧下颌颊侧装置各一 ,每装置有正常和 4小时人工龋釉质标本各 1块。有氟期氟片置于上颌中切牙前庭沟处的粘膜表面 ,每天一次 ,一次一片。实验后将正常釉质块放入 3 7℃酸胶中 4 8小时。观察两期人工龋表面硬度值的改变、表面沉积物的情况和实验后釉质抗酸能力的变化。结果 有氟期人工龋表面硬度值增加量 (上下颌分别为 73 .9± 6.3kg/mm2 和 3 5.1± 8.9kg/mm2 ,P <0 .5)高于无氟期 (上下颌分别为 55.9± 8.3kg/mm2 和 3 1 .1± 1 4.5kg/mm2 ,P >0 .5) ,上颌硬度值增加最多 ,P <0 .5。有氟期人工龋釉质表面有小而致密的矿物盐沉积 ,无氟期的沉积物大而疏松。有氟期正常釉质经酸处理后脱矿程度低于无氟期。结论 缓释氟粘贴片能提高唾液对早期龋的再矿化作用 ,增进正常釉质的抗酸能力。

Objective To evaluate the caries preventing effect of slow-release fluoride tablet in vivo.Methods Seven subjects with healthy gum and DMFT=0 were selected.Each wore two acrylic resin bases in control and test stage (4 weeks each).One base was placed on palatal surfaces of right maxillary molars,the other on buccal surfaces of left mandibular molars.Each base had a normal enamel cube and an enamel cube with early artificial caries.A fluoride tablet was adhered on the mucosa surface of maxillary anterior vestibule after each supper in the test stage.After experiment,microhardness values,sediment on enamel surface and histology changes of normal enamel treated by acid gel for 48 hours after experiment were examined.Results The increased microhardness values in the test stage (maxillary: 73.9 ± 6.3 kg/mm 2 mandibular: 35.1 ± 8.9 kg/mm 2,P< 0.5 ) were bigger than the control stage (maxillary: 55.9 ± 8.3 kg/mm 2,mandibular: 31.1 ± 14.5 kg/mm 2,P> 0.5 ).Irregular sediments were observed on enamel surfaces,and were rough and sparse in the control stage but small and compact in the test stage.There were an obvious surface layer and a wide subsurface demineralization layer in enamel of the control stage.Conclusion Slow-release fluoride tablet could enhance saliva's remineralization effect and improve the caries resistance of enamel.