糖尿病神经病变与抗神经节苷酯抗体关系探讨

Inquire into the relationship between diabetic peripheral neuropathy factors and antigangliosides antibody

目的 探讨 2型糖尿病周围神经病变 (DPN)与抗神经节苷酯 (GS)抗体的关系。方法 采用固相酶联免疫吸附法对 2型糖尿病神经病变和无神经病变以及其他神经病变和正常人进行抗神经节苷酯IgM、IgG抗体检测。结果 DPN组抗GS IgM、抗GS IgG抗体分别为 46 7%和 2 0 0 % ,明显高于无神经病变组和其他神经病变组及正常人。结论 抗神经节苷酯抗体与糖尿病周围神经病变关系密切 ,其在病理过程中可能起着重要作用。

Objective\ Inquire into the relationship between diabetic peripheral neuropathy(DPN)pathogenic factor and Antigangliosides antibody(Anti GS Ab)in type 2 diabetes mellitus. Methods \ It was examined by enzyme linked immunosorbent assays(ELISA)to the levels of serum Anti gangliosides(Anti GS)in 2 DM and DPN as well as healthy.Results\ The positive rate of Anti GS IgM,IgG in DPN group were 46 7% and 20.0%.repectivily it was obviously higher than normal group and 2 DM group.Conclusion\ The relationship between the DPN and Anti GS Ab is a close.It show that Anti GS Ab play an important role in DPN pathological process.