双氢青蒿素治疗实验大鼠卡氏肺孢子虫肺炎的疗效观察

A primary observation of therapeutic effect of dihydroartemisinin on experimental rats infected with Pneumocystis carinii

目的：研究双氢青蒿素抬疗实验大鼠卡氏肺抱子虫肺炎的疗效。方法：Ｗｉ丑ａｒ大鼠皮下注射醋酸可的松建立卡氏肺泡子虫肺炎动物模型。用双氢青蒿素治疗实验大鼠同时设有感染组和正常组作为对照。通过存活数、存活率、肺重、肺重／体树重比、包囊计数和肺组织病理学变化考核药物疗效。结果：治疗组大鼠存活数、存活率均高于感染组，而低于正常组；治疗组大鼠平均肺重、平均肺重／体重比和包囊数均低于感染组，肺组织炎症反应明显减轻。结论：双氢青蒿素是一种治疗大鼠卡氏肺孢子虫肺炎的有效药物。

Objective-.To study the therapeutic effect of dihydroartemisinin(DHA)on experimental rats infect- ed with Pneumocystis carinii. Methods :Wistar rat model of Pneumocystis carinii pneumonia (PCP) was estab- lished by subcutaneous injection with cortisone acetate and treated orally with dihydroarteminsinin. PCP rats and normal rats served as control. The therapeutic effect of DHA was evaluated by rat survival numbers, survival rate,lung weight,ratio of lung weight to body weight,cyst count and pathological changes. Results :Rat survival numbers, survival rate in the treatment group were much higher than that in the infection group, but lower than in the normal group. Average lung weight, average ratio of lung weight to body weight and cyst numbers in the treatment group were lower than in the infection group. Lung inflammation remarkably lightened in the treat- ment group. Conclusion :DHA was one of the useful drugs to treat PCP.