慢性肾功能不全患者尿中NAG、RBP和FDP检测及意义

The analysis of the relation between urinary NAG、RBP and urinary FDP in glomerulonephritis patients with chronic renal insufficiency

目的：探讨慢性肾功能不全（ＣＲＩ）患者尿Ｎ－乙酰－β－Ｄ－氨基葡萄糖苷酶（ＮＡＧ）、视黄醇结合蛋白（ＲＢＰ）与纤维蛋白降解产物（ＦＤＰ）变化及其意义。方法：应用比色法、酶联免疫法及乳胶凝集法分别检测２５例慢性肾小球肾炎ＣＲＩ患者和２８例健康对照组尿ＮＡＧ、ＲＢＰ及ＦＤＰ水平。结果：ＣＲＩ 患者尿ＲＢＰ含量、ＮＡＧ活性明显增高（Ｐ＜０．０１），且在尿ＦＤＰ阳性组及伴高血压的ＣＲＩ患者尿ＲＢＰ及ＮＡＧ升高更明显（Ｐ＜０．０５）。结论：ＣＲＩ患者残存肾单位肾小球内凝血以及伴有的高血压可能是其小管－间质损害加重的重要因素。

Objective: To analyse the relation and the significance between urinary N - acetyl- beta- d - glu- cosaminidase (NAG) retinol - binding protein (RBP) and products of fibrin degradation (FDP) in glomeru- lonephritis patients with chronic renal insufficiency (CRI). Methods: We measured the levels of urinary NAG、 RBP and FDP of the 25 cases of patients with CRI by use of colorimetry ELISA and latex coagulation test. Re- sults : The levels of urinary NAG RBP in patients with CRI were significantly higher than those in the control group, the levels of urinary NAG RBP in the positive group of urinary FDP were higher than those in the nega- tive group, and the levels in CRI patients with hypertension were higher than the levels in those without hyper- tension. Conclusion: The procedure of the coagulation in residual nephron and hypertension may be important factors in aggravating the tubulointerstitial lesion in glomerulonephritis patients with CRI.