急性脑梗塞患者血浆精氨酸加压素和内皮素及一氧化氮动态变化与脑梗塞的关系

Dynamic Levels of Arginine Vaso-pression,Endothelin and Nitric Oxide Cerebral Infarction

目的 :观察急性脑梗塞患者血浆精氨酸加压素 (AVP)和内皮素 (ET)及一氧化氮 (NO)的动态变化 ,探求这些物质与脑梗塞严重程度的关系。方法 :用放射免疫法 (RIA)和 Green's法检测36例急性脑梗塞发病 48、1 6 8、480 h共 3次及 30例正常人 (作为正常值 ) AVP、ET、NO水平。结果 :脑梗塞后 48和 1 6 8h的 AVP、ET显著高于正常值 ,P<0 .0 0 1和 0 .0 1 ;而 480 h后与正常值接近 ,P>0 .0 5。 NO在脑梗塞后 48和 1 6 8h,非常显著低于正常值 ,P<0 .0 0 1和 0 .0 1 :而 480 h接近正常值 ,P>0 .0 5。脑梗塞大梗塞灶组 AVP、ET显著高于小梗塞灶组 ,P<0 .0 1 ;而 NO大梗塞灶组显著低于小梗塞灶组 ,P<0 .0 1。结论 :AVP、ET、NO与急性脑梗塞发病后的时间和梗塞范围有密切的相关性 。

Objective: To investigate the dynamic plasma levels of arginine vaso pression (AVP),endothelin (ET) and nitric oxide (NO) in patients with cerebral infarction.Methods: The plasma concentrations of AVP, ET and NO in 36 patients on 48 hrs,168 hrs,480 hrs after acute cerebral infarction and 30 normal controls (as a normal value) were measured by radioimmunoassay (RIA) and Green's methods.Results: The plasma AVP and ET levels of 36 patients on 48 hrs and 168 hrs after infarction were significantly higher than the normal value (P<0.001 and P<0.01).There were no significant differences between the levels of AVP and ET on 480 hrs and the normal value (P>0.05). The NO levels on 48hrs and on 168 hrs after infarction were significantly lower than the normal value (P<0.001 and P<0.01). There were no significant differences between the levels of NO on 480 hrs after infarction and the normal value(P>0.05). The AVP and ET levels in the group of large infarction zone were significantly higher than those in the group of small infarction zone (P<0. 01). The NO levels in the group of large infarction zone were significantly lower than those in the group of small infarction zone ( P <0.01).Conclusion: AVP, ET and NO are related closely to the progressing time and the infarction range of acute cerebral infarction, so they can be used as a clinical indicater to judge the severity of acute cerebral infarction.