慢性宫颈炎合并人乳头瘤病毒感染的临床研究

Study about HPV-infection among the Patients with Chronic Cervicitis

目的了解慢性宫颈炎患者感染人乳头瘤病毒 (HPV)的情况。方法随机抽取慢性宫颈炎患者2 52例 ,根据免疫组化检测结果分为两组 :HPV Ag阳性组和HPV Ag阴性组 ,对比两组患者的年龄、临床表现 ,并行宫颈细胞学检查、阴道镜检查、病理活检 ,随后行宫颈电灼治疗 ,观察宫颈愈复情况及HPV Ag是否转阴。 结果宫颈炎中HPV感染率为 1 4 .68% ,感染后临床症状较HPV Ag阴性组重 ,阴道细胞学检查多为Ⅱ级或Ⅲ级 ,阴道镜下多为不典型转变区 ,病理切片可见空泡细胞。经电灼治疗后 ,阳性组70 .2 7%患者宫颈HPV Ag可转阴。 结论治疗HPV

Objective To study the HPV infection’s state in patients with chronic cervicitis.Method According to the result of determination of HPV Ag in cervical tissue by immunohiso chemical assay,252 patients with chronic cervicitis were devided into two groups:group A-HPV Ag positive,n=37,with a positive rate of 14.68%,and group B-HPV Ag negative,n=215.Results Comparing with group B.the clinical manifestations in group A were very prominen.In group A,the cytological assessments of vaginal smears of most cases were made as Papanicolaou’s grade Ⅱ～Ⅲ,while the majority of colposcopic observations showed atypical transformation,such as leukoplakia ete,at cervix and through biopsy the vacuous epithetial cells could be seen.After electrocautery,the 70.27% of the cases in group Ⅰ showed a negative turn of HPV Ag.Conclusion The proper treatment for HPV positive case with chronic cervicitis may be an active measure to prevent cervical carcinoma.