胃癌高发区不同人群血浆总抗氧化力及谷胱甘肽过氧化物酶活性的研究

Total Radical-Trapping Antioxidative Capacity and Glutathione Peroxidase Activity of Plasma in a High-Risk Area of Gastric Cancer

用微弱化学发光法和酶联分光光度技术研究胃癌高发区——甘肃省武威地区不同人群血浆总抗氧化力 ( TRAC)和谷胱甘肽过氧化物酶 ( GSH- Px)活性 .结果表明 :中度表浅性胃炎 18例、重度表浅性胃炎 2 1例、萎缩性胃炎 17例、胃癌 35例和食管癌 2 0例血浆 TRAC均较正常对照组2 1例明显降低 ( p≤ 0 .0 1) ,但各组间血浆 GSH- Px活性无显著性差异 ( p >0 .0 5) .提示当地胃癌高发可能与血浆 TRAC水平的降低有关 ,而与 GSH- Px活性改变无明显相关 .

By chemiluminescence assay and enzyme-linked spectroscopic analysis, the total radical-trapping antioxidative capacity (TRAC) and glutathione peroxidase (GSH-Px) activity of plasma were studied in various examined subjects of the area, Wuwei County of Gansu Province in Northwest China, with a high mortality of gastric cancer. The results showed: TRACs in moderate chronic superficial gastritis (N=18, 7.6±6.0, p<0.01), severe chronic superficial gastritis (N=21, 7.9±7.5, p=0.01), atrophic gastritis (N = 17, 5.1±4.4, p<0.001), gastric cancer (N=35, 3.0±2.1, p<0.001) and esophageal cancer groups (N=20, 3.6±2.5, p<0.001) were significantly lower than that of control group (14.9±9.9). But the GSH-Px activity of plasma had no significant statistic difference with each group. These results suggest that the TRAC fault may be involved in the high-risk of gastric cancer examined area while the GSH-Px activity is not conspicuously concerned with gastric carcinogenesis.