对氨基三氟甲苯合成工艺的进展

A Review of The Main Synthetic Processes of p-Aminobenzotrifluoride

本文对重要的医药、农药中间体 ,即对氨基三氟甲苯的主要合成工艺进行了评述 ,其中着重评述了对氯三氟甲苯的氨解 ,对三卤甲基苯异腈或N -对三卤甲基苯基卤代酰胺的氟解 。

p aminobenzotrifluoride is an important intermediate of medicines and agricultural Chemicals, but now is not produced in our country. In the present paper, three main synthetic processes concerning aminolysis of p \|chlorobenzotrifluoride, hydrolysis and exchange fluorination of p \|trihalomethylbenzoisocyanate or p\|tribhalomenthylbenzocarbamylhalide, and trifluoromenthylation of aniline are discussed in detail. Their reaction mechanism are investigated and their advantages and disadvantages are also compared.