抗真菌抗生素179M产生菌的分离鉴定和生理特性研究

ISOLATION，IDENTIFICATION AND CHARACTERIZATION OF A FUNGUS STRAIN PRODUCING ANTIFUNGAL ANTIBIOTIC

从大亚湾海底沉积物中分离出一株具广谱抗真菌作用的曲霉（编号为179），经初步鉴定为黄柄曲霉(Aspergillus flavipes)，该曲霉最适生长温度为36℃，最适生长pH为6。其抗真菌代谢产物179M对酵母类真菌的最小抑菌浓度为0.78-12.5μg/mL,对皮肤感染真菌石膏样小孢子菌(Microsporum gypseum)的最小抑菌浓度为1.56μg/mL，179M还能抑制多种植物病原真菌的生长。

A fungus strain producing a broad-spectrum antifungal antibiotic was isolated from the sediment of the South China Sea. The strain numbered 179 was initially identified as Aspergillus flavipes. The optimal temperature of the growth of 179 was 36℃ and pH 6 . The MIC against yeasts of the antibiotic 179M produced by this mould was 0.78~12.5μg/ml and 1.56μg/ml against Microsporum gypseum . 179M can also inhibit the growth of various species of phytopathogenic fungi.