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去脑皮层血管对大鼠前脑大细胞基底核AChE、ChAT、BDNF、trkB及其mRNA表达的影响 被引量：4

EXPERIMENTAL STUDY ON THE EFFECTS OF EXPRESSION OF AChE, ChAT, BDNF, trkB, BDNF mRNA, trkB mRNA IN THE MBN OF RAT FOREBRAIN AFTER CORTICAL DEVASCULARIZATION
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摘要 本研究采用去除大鼠皮层血管建立的血管性痴呆模型。去除皮层血管后 ,发现大鼠前脑大细胞基底核胆碱能神经元的ACh E、Ch AT、BDNF、trk B及其 m RNA的表达明显降低。结果说明 ,去皮层血管后造成的大细胞基底核的损害是继发皮质损害的逆行性变性 ,大鼠去皮层血管后 ,皮质、海马等处神经元靶源性的 BDNF、trk B及其 m RNA的表达降低 ,逆行性运输到大细胞基底核的胆碱能神经元的 BDNF减少 ,导致大细胞基底核神经元的变性。 In this study, wistar rat is used to establish a vascular dementia model by devasculating rat left cortex. The expression of AChE, ChAT, BDNF, trkB, BDNF mRNA, trkB mRNA decrease obviously in cholinergic neurons of magnocellular basal nucleus (MBN) after cortical devascularization. These results show that the degeneration of cholinergic neurons of magnocellular basal nucleus (MBN) is a retrograde cell degeneration after lesions of cerebral cortex. The expression of BDNF, BDNF mRNA decreased in cerebral cortex and hippocampus after cortical devascularization, leaded to degenerate of cholinergic neurons of magnocellular basal nucleus (MBN) by decreasing of target derived BDNF protein. (Figures a～j on plate 27)
作者 司银楚 朱培纯
机构地区 北京中医药大学解剖学教研室
出处 《神经解剖学杂志》 CAS CSCD 北大核心 2001年第2期161-165,T027,共6页 Chinese Journal of Neuroanatomy
基金 "九.五"国家攻关课题 (No. 96 -90 6 -0 9-0 3 )
关键词 ACHE CHAT BDNF TRKB mRNA 大细胞基底核 大鼠 去脑皮层血管 血管性痴呆 AChE, ChAT, BDNF, TrkB, mRNA, magnocellular basal nucleus (MBN), rat
分类号 R-332 [医药卫生]
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参考文献10

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同被引文献38

  • 1赖红,曾亮,赵海花,高杰,王铁民,吕永利.老龄大鼠海马结构脑源性神经营养因子表达的改变[J].解剖学杂志,2005,28(6):673-675. 被引量：7
  • 2Marini AM,Jiang X,Wu X,et al.Role of brain-derived neurotrophic factor and NF-kappaB in neuronal plasticity and survival:From genes to phenotype.Restor Neurol Neurosci,2004,22(2):121-130
  • 3Gorski JA,Zeiler SR,Tamowski S,et al.Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites.J Neurosci,2003,23(17):6856-6865
  • 4Narisawa-Saito M,Nawa H.Differential regulation of hippocampal neurotrophins during aging in rats.J Neurochem,1996,67(3):1124-1131
  • 5Lapchak PA,Aruujo DM,Beck KD,et al.BDNF and trkB mRNA expression in hippocampal formation of aging rats.Neurobiol Aging,1993,14(2):121-126
  • 6Croll SD,Nancy Y,Ronald M,et al.Expression of BDNF and trkB as a function of age and cognitive performance.Brain Res,1998,812(1-2):200-218
  • 7Liao B,Newmark H,Zhou R.Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro.Exp Neurol,2002,173(2):224-234
  • 8Salim KN,McEwen BS,Chao HM.Ginsenoside Rb1 regulates ChAT,NGF and trkA mRNA expression in the rat brain.Brain Res Mol Brain Res,1997,47(1-2):177-182
  • 9Marini AM,Jiang X,Wu X,et al.Role of brain-derived neurotrophic factor and NF-kappa B in neuronal plasticity and survival:from genes to phenotype.Restor Neurol Neurosci,2004,22 (2) :121-130.
  • 10Gorski JA,Zeiler SR,Tamowski S,et al.Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites.J Neurosci,2003,23(17) :6856-6865.

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神经解剖学杂志
2001年 第2期

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