凝集素受体在胃癌及其淋巴结转移癌中的分布

The distribution of lectin receptors In gastric carcinoma and lymph node metastatic tumors

目的探讨凝集素受体分布与胃癌及其淋巴结转移癌的关系。方法应用生物素标记的３种凝集素（Ｂｉｏｔｉｎ－ＰＨＡ，Ｂｉｏｔｉｎ－ＰＮＡ，Ｂｉｏｔｉｎ－ＤＢＡ）对人体胃癌的例，淋巴结转移癌３２例，正常胃粘膜1０例，进行亲合组织化学法（ＡＢＣ法）研究。结果发现ＰＨＡ、ＰＮＡ受体的分布与胃癌组织学类型及分化程度有关。ＰＨＡ、ＰＮＡ在胃癌中标记阳性率较高，对于胃癌的诊断是一个十分有用的探针。８１．３％淋巴结转移癌与其原发胃癌在凝集素标记的量上存在差异，并且比原发肿瘤获得更多的Ｎ受体。ＰＨＡ、ＰＮＡ在淋巴结转移癌中的标记阳性率较高，对于识别淋巴结是否转移具有一定的应用价值。结论胃癌中凝集素受体分布与其组织学类型及淋巴结转移癌有关。

Objective TO explore the distribution of lectin receptors and the relation with gastric carcinoma and lymph node metastatic tumors. Methods Three lectin(Biotin-PHA, Biotin-PHA, Biotin-DBA) were studied by affinity histochemical method in 66 cases of gastric carcinoma,32 cases of lymph node metastatic tumors and 10 cases of normal gastric mucosa. Results The resulte showed that the distribution of PHA and PNA receptors related to the histologic type and degree of differentiation. There were higher positive rates of PHA and PHA receptors in gastric carcinoma and it would be an useful probe to dignosis of gastric carcinoma. 81 .3% lymph node metastatic tumors produced cellular glycoconjugates which differed in their lectin binding profiles from those made by the cells in the respective primary carcinoma. The PHA receptor in the lymph node metastatic tumor was more than in the primary carcinoma. There were higher positive rates of HPA and PHA receptors in lymph node metastatic tumors. Conclusion The lectin distrbution and histological types were related with lymph node metastatic carcinoma.