丙咪嗪和西沙必利治疗功能性消化不良的对比研究

Comparative study on teatment of functional dyspepsia by imipramine and cisapride

目的 评价丙咪嗪对功能性消化不良的疗效。方法 使用丙咪嗪、西沙必利治疗 4周 ,然后进行疗效比较。结果 两组间一般症状的改善比较差异无显著性 ,而优势症状及总体症状比较差异有显著性 ;丙咪嗪组总积分下降前两周慢 ,后两周快 ;两组间胃半排空时间改变比较差异有显著性 ;患者有轻～中度抑郁焦虑 ,改善程度两组间比较差异无显著性。结论 两药改善一般症状的疗效相近 ,西沙必利明显改善优势症状 ;丙咪嗪起效慢 ,两周后作用加强 ,无促动力作用 ;轻～中度抑郁焦虑的患者 ,被两药改善的程度接近。

Objective To evaluated the curative effect of imipramine for functional dyspepsia(FD) and comparing with cisapride. Methods In the end of 4 weeks of the therapeutic duration with imipramine and cisapride, the effectiveness were evaluated. Results The improvement of general epigastric symptoms in two groups showed no statistical significant difference, but the improvement of predominant symptoms and the total score of dyspepsia symptoms showed significant difference. The decrease of the total score of dyspepsia symptoms in imipramine group are slower during the first 2 weeks and accelerated during the second 2 weeks. There is significant difference in the decrease of GET1/2 between two groups. But there was no statistical significant difference between slight or mild depression and anxiety. Conclusion With regard to the improvement of the general dyspeptic symptoms of dysmotility like FD, the effectiveness of imipramine is equal to cisapride. More apparent improvement of the dyspeptic symptoms during the second two weeks than the first ones in the therapeutic duration was found in imipramine group than those of cisapride. imipramine had little prokinetic effect. And the patients with imipramine and cisapride therapy have significant improvement in slight or mild depression and anxiety, with equal effect in this regard.