先天性胫骨假关节(CPT)的超微结构

Ultrastrutural Study of Congenital Pseudoarthrosis of the Tibia

目的 :深入了解先天性胫骨假关节 (CPT)的病理变化、细胞类型及其病变来源。方法 :取 5例先天性胫骨假关节 (CPT)标本中不同部位的组织 2 0例 ,经固定、切片染色后置于透射电镜下进行观察。结果 :(1)断端间组织及病变骨膜组织性质完全一样 ,均为致密纤维结缔组织 ,细胞成分多 ,主要为纤维母细胞、肌纤维母细胞及少量未分化细胞。(2 )移行部位骨膜组织结构与病变处骨膜组织结构相似。 (3 )断端处骨质细胞稀少 ,部分骨细胞萎缩或坏死 ,部分骨细胞含有空泡 ,骨基质未见异常。 (4)移行部位骨质未见明显异常表现。结论 :(1)先天胫骨假关节 (CPT)是非神经起源的、而是起源于骨膜的一种细胞增生活跃的纤维增生性变 ;(2 )

Objective:To investigate the pathological changes and kinds of cell and origin of congenital pseudoarthrosis of tibia(CPT).Method:20 different specimens were taken from 5 CPT patients.By electron microscopy all specimens were studied after fixation and dyeing.Result:(1) The soft tissue interposed between the CPT bone ends had the same pathological change as CPT periosteum.Both of them were proliferated dense connective tissues in which there were a large number of cellular components and collagen fibers,including plenty of fibroblast and myofibroblast and some indifferential cells.(2)The pathological change of the periosteum between the normal periosteun and CPT periosteum was similar to the CPT periosteum.(3)Resorption and necrosis happened to the bone ends at the CPT lesion,but bone matrix appeared to be normal.(4)There were not obviously abnormal appearance in the bone between the normal bone and CPT bone end.Conclusion: (1)CPT is a non-neuro original but periosteum original fibrosis which had a strong activity of cellular proliferation and corrosion.(2)Myofibroblast played an important role in the pathogenesis of CPT.