小剂量善宁治肝硬化食管静脉曲张破裂出血的临床研究

The Clinical Study on Treatment of Esophageal Variceal Bleeding with Small Dose of Sandostatin

的 :探讨小剂量善宁治疗肝硬化门脉高压食管静脉曲张破裂出血的疗效并与常规量进行比较。方法 :6 3例病人随机分为二组。A组 (小剂量善宁组 ) :善宁 0 .1mgiv后 ,以 12 .5 μg/hivdrip维持 72小时 ;B组 (常规量善宁组 ) :善宁 0 .1mgiv后 ,以 2 5 μg/hivdrip维持 72小时。分别观察 2 4小时、2 4～ 72小时内出血停止情况及出血停止 1周内再出血情况 ,并记录副作用。结果 :A、B两组 2 4小时内止血率分别为 5 9.3 %和 6 4.5 % ;2 4～ 72小时内止血率分别为84.4%和 87.1% ;出血停止后 1周内再出血率分别为 3 .12 %和 3 .2 2 %。两组均未出现明显副作用。两组在显效率 ,有效率和 1周内再出血率方面疗效相当 ,无统计学差异 (P >0 .0 5 )。结论 :小剂量善宁方案以其高效、经济。

Purpose: The effect of using small dose sandostatin was compared with routine dose sandostatin for esophageal varical bleeding. Metahods: 63 patients with EVB bolus injection and 12.5 μmol/L iv infuoion for 72 h; 31 cases were assigned to use rotine dose sandostatin 0.1 mg iv and 25 μmol/L iv dropping for 3 days. To observe 24 h hemostasis, 24～72 h hemostasis, rebleeding and side effect. Results: 24 h hemostasis rates in group A and B were 59.3% and 64.5%, 24～72 h hemostasis rates were 84.4% and 87.1% and 87.1%, rebleeding rates were 3.12% and 3.22% respectively. There was no significant side effect in two groups. The results indicate that the hemostasis rates and rebleeding rates were no significant satisically betweeen the two groups (P>0.05). Conclusion: The small dose sandostatin is an effective, economical simple to use and well tolerated of EVB therapy.