摘要
目的 :探讨 Survivin基因表达与宫颈癌发生发展的关系。方法 :应用免疫组化技术 (SP法 ) ,检测Survivin基因在 10例正常宫颈组织、5例上皮内瘤样变及 5 9例宫颈鳞癌中的表达。结果 :Survivin在正常宫颈组织中不表达 ,在宫颈上皮癌变过程中表达阳性率逐级升高。Survivin表达阳性率与宫颈癌的组织学分级和临床分期呈正相关。结论 :Survivin基因表达发生在宫颈癌恶性转化的早期 ,并为宫颈癌预后提供了有价值的判断指标。
Objective:To study the expression of survivin gene in cervical carcinoma and its relation to the pathogenesis of cervical carcinoma.Methods:Using SP immunohistochemical technique,we examined 74 cervical tissues of clinicopathological specimens,including 10 normal cervical tissues,5 cervical intraepithelial meoplasia(CIN)lesions,59 invasive squamous cell carcinomas.Rusults:Expression of survivin were not observed in normal cervical tissues. With the lesions progressing ,the expression rate of survivin protein had a increasing tendency.Expression of survivin was related to the tumor grade and clinical stage.Conclusion:The results suggested that survivin expression is the essential event in carcinogenesis and development of cervical carcinoma.Survivin expression in cervical carcinoma is a useful prognostic marker.
出处
《肿瘤研究与临床》
CAS
2001年第4期229-231,共3页
Cancer Research and Clinic
