反复自然流产患者心理因素与肿瘤坏死因子含量的改变

Psychosocial aspects and changes of TNF content in the patients with recurrent spontaneous abortion

目的 探讨心理因素与肿瘤坏死因子在反复自然流产中的致病作用。方法 采用反复自然流产妇女问卷、精神压力自评、症状自评量表等方法对 6 9例反复自然流产妇女和 6 9例正常生育妇女的精神心理状况进行了测评 ,同时选择部分病例检测其血清中细胞因子TNF水平的改变。结果 反复自然流产妇女 91%感到精神压力 ,对再次妊娠产生恐惧感 ,与正常生育组比较精神症状多 ,抑郁程度高 ,焦虑频度高 ,心理压力大。反复自然流产妇女血清中TNF的水平比对照组明显升高(P <0 .0 1)。结论 反复自然流产妇女与心理社会因素有关 ;

Objective The study was designed to explore pathogenicity of mental factors and tumor necrosis factor (TNF) in patients with recurrent spontaneous abortion (RSA).Methods 69 cases of patients with RSA and 69 cases of normal pregnant women were studied with RSA questionnaire , mental prensure self evaluation and symptom checklist 90(SCL 90). Serum TNF content was also tested.Results 91% of RSA patients have mental pression and were afraid to again pregnacy. Highly on anxiety depression and somatic symptoms were scored,which was related with occupation and degree educated compared with normal controls. TNF level of serum in the patients with RSA was higher than controls. Conclusion RSA patients were related with psychosocial factors,TNF participate in pathogenicity of RSA.