卡巴匹林钙的一锅烩合成工艺改进

An Improvement on the One-pot Synthetic Technology of Carbasalate Calcium

用丙酮和热乙醇为溶剂 ,在室温下通入NH3,短时间内可制成卡巴匹林钙。用Rf 值、IR和1H NMR对化合物结构进行表征。对影响反应的诸因素进行了优化。产率由 74 6 %提高到95 4% ,反应时间由 2h缩短至 2 5min。

Acetone and hot-ethanol were used as solvents,taken in NH 3(gas)at room temperature,carbasalate calcium was prepared by One-pot synthetic technology after a short time.Its structure was characterized by IR,R f and 1H-NMR.Some experimental conditions were optimized.The yield of carbasalate calcium was increased from 74 6% to 95 4% under proper conditions.The time was shortened from 2 h to 25 min ,as compared with the classic method.