长期吸入糖皮质激素对哮喘患者某些骨代谢指标的影响

Effects of long-term inhaled steroid therapy for asthma on bone density and calcium metabolism

目的 了解南京地区哮喘患者长期吸入类固醇糖皮质激素 ( GCS)是否会引起骨质丢失。方法 采用双能 X线骨密度仪( DEXA)和放免法等分别测定 2 0例每日坚持吸 GCS大于等于五个月的哮喘患者的骨密度 ( BMD)、血骨钙素 ( BGP)等指标 ,并同期配对 2 0例未使用 GCS的哮喘患者进行对比分析。结果 显示两组病人 BMD和 BGP等各指标之间无显著差异 ,P>0 .0 5。结论 在一定限度内长期吸入 GCS控制哮喘 。

Objective To investigate whether prolonged treatment with inhaled steroids has a detrimental effect on bone mass and metabolism.Methods We measured bone density and osteocalcin in 20 asthmatic patients after treatment with an inhaled seroid for more than 5 months,and compared them with a control group of 20 asthmatic patients using no steroids.Result There are no significant difference between our two groups in bone density and other markers of bone metabolism(P>0.05).Conclusions This study showed that long-term inhaled steroids,in the range of doses used,has no adverse effects on bone density and other makers of bone metabolism in asthmatic patients.