ACE I/D AT1R A1166C基因多态性与高血压性脑卒中的关系

The Relation of ACE I/D ATIR A1166C Gene Polymorphism to Ischemic Stroke

目的:探索血管紧张素转换酶(ACE)基因I/D和血管紧张素Ⅱ受体1(AT1R)基因A1166C多态性与高血压性脑卒中的关系和两基因之间的作用对高血压性脑卒中发病的影响。方法:我们用PCR的方法检测86例缺血性脑卒中病人,51例高血压病人和58例正常人的ACE I/D和AT1R A1166C多态性。结果:高血压性脑卒中组的ACE DD型基因和D等位基因的频率高于高血压性非卒中组。同样,高血压性脑卒中的AT1R AC+CC型基因和C等位基因和频率也高于高血压非卒中组。结论:ACE DD基因和C等位基因、AT1R AC CC型基因和C等位基因是高血压性脑卒中的危险因子。

Objective: The of the study is to identify whether ACE gene I/D and AT1R gene A1166C polymorphisms are related to the development of hypertensive ischemic stroke. Methods: 86 cases of the in-patients with ischemic stroke, 51 hypertensives, and 58 controls were genotyped for ACE I/D and AT1R A1166C polymorphisms by polymerase chainreaction (PCR). Results: The frequencies of ACE DD geno-type and D allele in the hypertensive patients with ischemic stroke were higher than those without ischemic stroke. Meanwhile, the frequencies of AT1R AC + CC genotype and C allele in the hypertensive patients with ischemic stroke were also higher than those without ischemic stroke. Conclusion: ACE DD genotype and D allele, AT1R AC CC genotypes and C allele may be the risk factors of the hypertensive ischemic stroke.