低血清胆红素与急性动脉硬化性脑梗死的关系

Relation between low serum bilirubin level and acute arteriosclerotic cerebral obstruction

目的 :探讨血清胆红素浓度与急性动脉硬化性脑梗死的关系。方法 :测定 2 16例急性脑梗死患者血清胆红素浓度 (分为脑梗组 13 4例 ,腔梗组 82例 ) ,98例健康体检者和 84例其它疾病组作对照。结果 :脑梗组间接胆红素显著低于对照组、其它疾病组 ( t=6.43 8,t=6.5 17,P <0 .0 0 1) ,也显著低于腔梗组 ( t=2 .741,P <0 .0 1) ;腔梗组间接胆红素显著低于对照组和其它疾病组 ( t=2 .782 ,t=2 .774,P均 <0 .0 1) ,直接胆红素四组间无显著差异。脑梗死灶容积与间接胆红素水平呈负相关 ,差异有非常显著性 ( r =-0 .73 9,t=14 .2 7,P <0 .0 1)。结论 :提示低血清胆红素可作为动脉硬化性脑梗死的独立危险因素。

Objective:It is to investigate the relation between serum bilirubin level and acute arteriosclerotic cerebral obstruction. Methods: 216 cases with acute cerebral obstruction were divided into two groups. 134 cases were in cerebral obstruction group and 82 cases were in cavity obstruction group. 84 cases with other diseases were formed for other patients group. 98 cases of healthy people were located for controlled group. The serum bilirubin was measured in four groups. Results: The serum level of indirect reacting bilirubin in cerebral obstruction group was significantly lower than that in controlled group (t=6.438, P<0.01), in other patients group(t=6.517, P<0.001)and in cavity obstruction group (t=2.741, P<0.01). The serum level of indirect reacting bilirubin in cavity obstruction group was also significantly lower than that in controlled group and in other patients group (t=2.782, t=2.774, P<0.01). For the serum level of direct reacting bilirubin, there were no significant changes being observed among the four groups. The capacity of cerebral obstruction was negatively correlated to the serum level of indirect reacting bilirubin (r=-0.739, t=14.27, P<0.01). Conclusion:Low serum bilirubin level may be regarded as a risk factor of arteriosclerotic cerebral obstruction and it is valuable for studying the pathogenesis and taking preventive measures to this disease.