丙二腈酰胺类免疫抑制剂的研究及应用进展

Progress in research and application of malononitrilamides—?  new class of immunosuppressant

综述了一种新型免疫抑制剂———丙二腈酰胺类 (MNAs)的作用机制及在器官移植动物模型、自身免疫性疾病等方面的应用进展。介绍了国外对该类免疫抑制剂用于治疗移植排斥反应及自身免疫性疾病的研究状况 ,并概述了该类免疫抑制剂与其他免疫抑制剂联合用药的情况。该类免疫抑制剂的代表———来氟米特 ,目前仅有片剂剂型上市 。

Malononitrilamides is a new class of immunosuppressant.Leflunomide is the representative of this class and leflunomide tablet was the only marketed dosage.In this paper,the mechanism of malononitrilamides and progress of their uses in single or combination treatment of allograft and xenograft rejection and autoimmune disease were reviewed. [