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高通量药物筛选在新药研究中的应用 被引量:27

Application of high throughput screening in drug development
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摘要 The techniques used in the field of drug discovery have been quickly developed during the past decades High throughput screening (HTS) is a new technique in drug discovery with the characteristics of efficiency, huge scale and automatically operation The assay methods used in HTS are based on the molecular targets and cells Screening results obtained from these methods indicate not only the bioactivities of compounds (samples) but also the mechanisms of actions of the compounds (samples) HTS has altered the strategy of drug The techniques used in the field of drug discovery have been quickly developed during the past decades High throughput screening (HTS) is a new technique in drug discovery with the characteristics of efficiency, huge scale and automatically operation The assay methods used in HTS are based on the molecular targets and cells Screening results obtained from these methods indicate not only the bioactivities of compounds (samples) but also the mechanisms of actions of the compounds (samples) HTS has altered the strategy of drug development
作者 杜冠华
出处 《基础医学与临床》 CSCD 北大核心 2001年第4期289-293,共5页 Basic and Clinical Medicine
基金 国家自然科学基金 (30 0 116 1940 ) 国家"九五"攻关计划项目 (96 90 1 0 2 0 9)
关键词 高通量药物筛选 药物研究 理论基础 酶活性 反向药理学 新药 drug discovery high throughput screening (HTS)
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