低剂量辐射(LDR)对淋巴细胞的效应(英文)

THE EFFECTS OF LOW DOSE RADIATION (LDR) ON LYMPHOCYTES

LDR能刺激成人、儿童和婴幼儿的淋巴细胞转化 ,对营养不良儿童的刺激效应较低 ,对脐血则刺激效应较明显。LDR对成人CD4 细胞的刺激效应强于CD8细胞 ,而以同样的刺激效应 ,NK细胞则需要较大剂量。对淋巴细胞NK活性也有同样规律。肿瘤病人的NK活性的刺激效应低于正常人。LDR增加了小鼠的血和脾内的T辅助 /诱导细胞的比例和肿瘤内T细胞毒性细胞。低剂量照射的淋巴细胞外液也能刺激淋巴细胞转化。预先LDR可以减轻随后大剂量照射引起的生物大分子、膜抗原和染色体的损伤。LDR可诱导鼠脾淋巴细胞产生新蛋白 ,它能增强人和动物的免疫功能。

LDR could stimulate lymphocyte transformation for adults,children and infants. The effect of LDR on lymphocytes in malnourished children was lower, but higher on lymphocytes in cord blood. The effect of LDR on CD + 4 cells in adult persons was higher than that on CD + 8 cells. NK cells were radioresistant.The stimulative effect of LDR on NK activeity in tumor patients was lower than that in normal individuals.For the mice with tumors, LDR could increase the ratio of L 3T 4 cells in blood,spleen and the number of cytotoxic T cells in the tumors. Extracellular fluid of the lymphocytes operated by LDR could also stimulate the lymphocyte transformation.The preliminary LDR could decrease the injuries to macromolecules membrane antigens and chromosomes in lymphocytes which were induced by high dose radiation. The LDR induced protein might be found from mouse spleen cells, and this protein could increase immune function in human and animals.