局限性淀粉样物沉积症的组织化学及免疫组织化学的研究

Histochemical and Immunohistochemical Studies on Localized Amyloidosis

应用组织化学和免疫组织化学的方法对18例局限性淀粉样物沉积症进行了分析和研究,探讨不同类型病变的形态学特征和发病机理,并提出诊断该病的可靠方法。

Histochemical and immunohistochemical studies on eighteen cases with localized amyloidosis were performed. The results showed that 13 cases were immunoglobulin light chain(AL) protein type, 1 case was mixed type of AL and AA protein, 4 cases were endocrine related amyloid (AE)protein type. Most of cases were seen with infiltration of plasma cells around the amyloid substances in AL type amyloidosis. It is possible that both the production of the precursor protein and its processing of amyloid fibrils take place locally. On the other hand, the mechanism of amyloid produced in endocrine organs is discussed.