急性乙型肝炎病人的肥大细胞脱颗粒试验及血清中组织含量的检测

Mast Cell Degranulation Test and Serum Histamine Levels of Patients with Acute Type B Hepatitis

本文对急性乙型肝炎急性期病人和正常人进行了间接HBsAg特异性和非特异性肥大细胞脱颗粒试验,并采用荧光测定法检测了血清中组织胺含量。结果表明,急性乙型肝炎病人的间接特异性和非特异性肥大细胞脱颗粒阳性率及血清中组织胺含量均显著高于正常对照组,p<0.01。提示,IgE及其介导的免疫反应可能参与急性乙型肝炎的发病机理。

Mast cell degranulation test of the Patients with acute type B hepatitis was performed by iudirect specific and nonspecific procedure. Histamine levels in serum from the patients was measured by fluorometry. The experimental results showed that the positive rate of mast cell degranulation of the patients and histamine levels in serum from the patients were significantly higher than that of normal group(P<0.01). These results suggested that IgE and IgE-mediated immunoreaction could involve in pathogenesis of acute type B hepatitis.