人体早期肝硬化病变(HBsAg阳性)的光、电镜对比观察

Observation on Pathological Changes of Hepatocirrhosis in Early Stage (HBsAg Positive) with Optical and Electron Microscope

本文从黑龙江地区肝癌切除标本中,筛选出癌旁肝组织呈早期肝硬化病变,且HBsAg阳性病例12例。对早期肝硬化病例进行了光、电镜对比观察,对超微病变的特点及癌变的关系进行了讨论,提出了微循环障碍为早期肝硬化的特点。新生肝细胞对小剂量致癌物质的敏感性,可能成为癌变机理中的重要环节。

From specimens of the excised liver in Heilongjiang Province, pathological changes of cirrhosis of the liver in early stage were sifted out by cancer tissue,among them were 12 cases with HBsAg positive reaction. The optical and electronic microscopic contrast observations on pathological changes of cirrhosis of the liver in early stage were made. The relation between ultrastructural changes and canceration was discussed. The results showed that microcirculatory disturbace is character of hepatocirrhosis in early stage and that neoformative hepatic cells have the sensitivity to a small dose of carcinogenic substance, which may become the key link of canceration mechanism.