摘要
本文以风心病二尖瓣病变合并被动性肺动脉高压为研究对象，借助右心导管技术和利用压力波形面积确定动脉顺应性的改进方法，通过测定肺血管阻力和顺应性，以评价慢性肺动脉高压肺血管力学特性的变化规律。发现慢性肺动脉高压患者肺动脉血管阻力明显升高（Ｐ＜０．０１）；而反映血管壁固有结构的零压顺应性 Ｃｏ明显下降（Ｐ＜０．０１），与术前肺动脉平均压呈显著负相关（ｒ＝－０．７４５，Ｐ＜０．０５）；扩血管药物试验提示不同程度肺动脉高压组的肺血管阻力均有显著下降（Ｐ＜０．０１），轻度肺高压组零压顺应性和平均压顺应性均明显升高（Ｐ＜０．０１）；而重度肺高压组零压顺应性 Ｃｏ无明显变化（Ｐ＞０．０５）。由此我们认为慢性肺高压肺血管都存在不同程度的重建，肺血管外周血管阻力和顺应性是影响其肺动脉压力水平的主要因素。
In this paper, we studied the pulmonary artery mechanical properties of the patient with chronic pulmonary hypertension. We selected the patients with pulmonary hypertension secondary to rheumatic mitral valvular disease, and measured pulmonary thenal resistance and compliance. The results showed a significantly lower in the pulmonary artenal compliance (Co) and resistance of patients with pulmonary hypertension as compared to the controls (p<0.01). Linear correlation analysis showed that preoperative PAPm correlated closely with Co (r=0.745, p<0.05). we measured the changes of the pulmonary circulation hemodynamics and arterial compliance while infusing Sodium Nitroprusside(0. 5 ug/min' kg). In group of mild pulmonary hypertension (PAPm
出处
《医用生物力学》
EI
CAS
CSCD
2001年第2期86-89,共4页
Journal of Medical Biomechanics
关键词
慢性肺动脉高压
肺血管顺应性
肺血管阻力
血管壁重建
chronic pulmonary hypertension, pulmonaly artery compliance, pulmonary vascular remodeling, pulmonary arterial resistance
