人血白蛋白治疗肾综合征出血热低血压休克患者疗效观察

THE CLINICAL EVALUATION ON HUMAN ALBUMIN FOR PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME

目的 观察人血白蛋白对肾综合征出血热低血压休克期的治疗效果。方法 采用回顾性对照的比较方法 ,治疗组在应用晶体液的同时 ,尽早应用人血白蛋白。对照组按“先晶后胶 ,晶 3胶 1”的补液原则治疗 ,胶体液用低分子右旋糖酐。结果 治疗组在血红蛋白降至正常时间 ,血压升至正常时间 ,少尿持续时间、尿蛋白阳性时间及血肌酐恢复正常时间均较对照组明显缩短 ,P <0 .0 1。治疗组在住院时间上与对照组相比也明显缩短 ,P <0 .0 5。结论 尽早应用人血白蛋白治疗优于以往的“先晶后胶 ,晶 3胶 1”的液体疗法 ,它可减轻外渗 ,使休克尽快得以纠正 ,从而减轻低血压休克对肾脏的损害 ,缩短少尿期 ,使肾功能损害尽快恢复。

Objective\ To study the therapy effect of human albumin (HA) for patient with hemorrhagic fever with renal syndrome (HFRS) during hypotension-shock phase.Methods\ The patients were divided into two groups.The difference for their treatment was only the HA intraveneous perfusion (the study group) or not (the control group).Results\ Comparied with the control group,the blood hemoglobin concentration,the blood creatinine concentration,and the blood pressure were returned to the normal levels much quickly in the study group (P<0.01),and the oliguric phase or the duration of hospitalization was shortened in the group (P<0.05).Conclution\ In patients with HFRS HA used in early stage is easy and effective.