贴壁细胞β射线内照射吸收剂量的计算

Calculation of absorbed dose of anchorage-dependent cells from internal beta-rays irradiation

目的 寻求贴壁细胞β射线内照射吸收剂量的计算公式。 方法 根据辐射吸收剂量定义和MIRD方案进行推导。从悬浮细胞培养模式入手 ,考虑到贴壁细胞培养的特殊性 ,以及其受照射的方向 ,依据累积放射性活度、β射线能量、培养液质量计算辐射吸收剂量。 结果 得到悬浮细胞、贴壁细胞 β射线内照射吸收剂量的计算公式。并进行计算验证。 结论 该公式使用简便 ,可靠性强 ,准确性好 ,便于实际应用。

Objective\ To elicit the formula of internal dosimetry in anchorage\|dependent cells by beta\|emitting radionuclides from uniformly distributed volume sources. Methods\ By means of the definition of absorbed dose and the MIRD(Medical International Radiation Dose) scheme the formula of internal dosimetry was reasonably deduced.Firstly,studying the systems of suspension culture cells.Then,taking account of the speciality of the systems of the anchorage\|dependent cells and the directions of irradiation,the absorbed dose of anchorage\|dependent cells was calculated by the accumulated radioactivity,beta\|ray energy,and the volume of the cultured systems. Results\ The formula of internal dosimetry of suspension culture cells and anchorage\|dependent cells were achieved.At the same time,the formula of internal dosimetry of suspension culture cells was compared with that of MIRD and was confirmed accurate. Conclusion\ The formula of internal dosimetry is concise,reliable and accurate.\;