氢溴酸山莨菪碱对哮喘患者支气管反应性的作用观察

EFFECTS OF ANISODAMINE ON BRONCHIAL REACTIVITY IN ASTHMATIC PATIENTS

本文对12例哮喘患者吸入氢溴酸山莨菪碱(654-2)后进行乙酰甲胆碱支气管激发试验,观察该药对支气管高反应性的影响,并与硫酸阿托品相比较。结果表明:654-2可明显降低支气管高反应性,用药后提高乙酰甲胆碱-PC_(20)均值4.889±3.96mg/ml,逊于硫酸阿托品,支气管扩张作用与最大作用时间和硫酸阿托品相近。

Anisodamine (654-2) was administered by inhalation to 12 asthmatic patients, and bronchial hyper-reactivity was studied by methacholine provocation test. The results were compared with atropine sul-fate. It was showed that anisodamine significantly reduced bronchial hyperreactivity. It increased the mean PC20 of methacholine test by 4.889±3.96mg/ml, and it was lower than that of atropine sulfate. But its bronchodilatation and maximum effect time was similar to that of atropine sulfate.