幼儿手背丘疹皮炎与病毒感染的实验研究

VIRUS INFECTION AND INFANTILE PAPULAR DERMATITIS OF DORSUM OF THE HAND

通过对幼儿手背丘疹性皮炎25例患者的粪便和咽拭子标本进行病毒分离培养,结果获得肠道病毒4株,腺病毒1株,经鉴定肠道病毒为CoxsA_9 2株,ECHO_(25) 1株。用所分离的病毒作为抗原对43例患者和40名健康者进行血清学对比研究。结果病毒感染和患者之间有明显相关性。同时对26例患者进行了双份血清学检测,结果CoxsA_9病毒组患者的血清抗体滴度>1:16,阳性率达80.77％,而ECHO_(25)病毒和腺病毒组的血清抗体滴度均<1:16,从而证明本组患者中CoxsA_9病毒感染与本病可能密切相关。

Four strains of enterovirus and 1 strain of adenovirus have been isolated from stool and pharyn-geal swab by inoeubation with primary human embryonic kidney cell culture in 25 cases of infantile , papular dermatitis of the dorsum of the hand. Two strains of Coxsackie A-9 virus and 1 strain of Echovirus-25 were identified. With the isolated virus as antigen, a matched pair study of the ser antibody test was carried out in 43 children with papular dermatitis and in 40 normal individuals as controls. In 26 cases of Coxsackie A-9 viruspositive papular dermatitis, a 4-fold rise (>1:16) of the relative serum antibody has been observed in 80%, while none of this high level was observed in patients with Echovirus-25 and adenovirus dermatitis (<1:16).We can reasonably conclude that epidemic Coxsackie A-9 virus infection was obviously related to infantile papular dermatitis and probably the main cause of the disease.