家兔下颌骨植入多孔型生物活性玻璃陶瓷颗粒的组织学观察

EXPERIMENTAL IMPLANTATION OF POROUS BIOACTIVE GLASS CERAMIC PARTICLES IN THE RABBIT'S MANDIBLE-----A HISTOLOGICAL STUDY

用多孔型生物活性玻璃陶瓷颗粒在15只家兔的下颌骨上作骨膜上和骨膜下种植,获取种植后1周、2周、1个月、3个月及6个月的标本。经光镜、荧光显微镜及扫描电镜观察表明:该材料组织相容性好,骨膜下种植后1周局部已有新骨生长;1个月可见新骨与种植颗粒形成骨性结合;6个月颗粒微孔中有骨组织长入。骨膜上种植,经6个月的观察未见局部有骨组织生长,部分颗粒有轻度吸收。提示用该材料作骨成形修复时应行骨膜下种植。

Porous bioactive glass ceramic particles were implanted into the mandible in 15 rabbits subperios-teally and supraperiosteally. Specimens obtained 1 week, 2 weeks, 1 month, 3 and 6 months after the implantation were observed with light, fluorescent and scanning electron microscopes. It was found that the material was compatible with tissues, and the new bone tissue was found 1 week after subperiosteal implantation. There was bony union between newly formed bone and bioactive glass ceramic particles 1 month later, and new bone grew into the porosity of the particles half a year after operation. No new bone formation was found in the supraperiosteal site in 6 month period of observation. It is concluded that the porous bioactive glass ceramic particles possessed of excellent biological compatibility, and they should be implanted subperiosteally if new bone formation were to be expected.