S-100蛋白在恶性间皮瘤中的分布及其意义

DISTRIBUTION AND SIGNIFICANCE OF S-100 PROTEIN IN MALIGNANT MESOTHE-LIOMAS

应用S-100蛋白对恶性间皮瘤16例和腹膜转移性胃肠道腺癌20例进行了免疫组化研究。其结果表明,恶性间皮瘤16例对S-100蛋白染色阳性者有14例,而腹膜转移性胃肠道腺癌均呈阴性。作者认为,由于S-100蛋白标准化抗体有市售,无论在尸检标本或手术切除标本中,当恶性间皮瘤与腹膜转移性胃肠道腺癌鉴别诊断发生困难时,不妨使用这种肿瘤标记物的免疫组化法以助诊断。

Immunohistological methods were used to investigate the presence of s-100 protein in 16 cases of malignant mesothelioma (MM) and 20 metastatic gastrointestinal adenocarcinoma of peritoneum. Positive staining for s-100 protein was observed in 14 of 16 MM, while it was negative in all metastatic gastrointestinal adenocarcinoma of peritoneum. Since antibodies to s-100 protein are readily available as standardised commercial products, the combined immunolocalisalion of s-100 protein should prove to be an efficient routine means of differentiating MM from difficult cases of metastatic gastrointestinal adenocarcinoma of peritoneum, in both necropsy and surgical cases.