摘要
用MG系列鼠抗人胃癌单克隆抗体免疫酶法对直肠癌、良性肠道疾病及正常人血清中一组新的肿瘤相关抗原(MG-Ags)进行检测,并观察其手术前后血清中含量的变化,以探讨其在直肠癌诊断中的价值。以25名正常人血清MG-Ags检测OD值的均数加3个标准差之和,作为判断肿瘤的阳性阈值,直肠癌患者33例MG-Ags检出阳性率为69.7%,良性肠道疾病25例假阳性率仅为4%。对5例行直肠癌切除术的MG-Ags阳性病人,术后8~10天检测血清中MG-Ags水平明显降低。实验结果提示,MG~Ags检测对直肠癌具有较高的临床应用价值。
A new group of gastric cancer associated antigens in sera of patients with rectal cancer, benign diseases and normal human were detected by MG series monoclonal antibodies against gastric cancer. The average values of normal persons plus 3 standard deviations was set as the highest limit of normal value. The positive rate were 69.7% (23/33) in sera of patients with rectal cancer, and 4%(1/25) in sera of patients with benign diseases. The values of MG-Ags were decreased to normal level 8-10 days after surgical removal in 5 patients of rectal cancer. The results of test suggest that determination of MG-Ags in serum of patients might be helpful in the diagnosis of rectal carcinoma.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1991年第4期250-251,共2页
Medical Journal of Chinese People's Liberation Army
关键词
直肠肿瘤
抗原
抗体
诊断
Rectal noeplasm Antigen Antibody Diagnosis