实验性多系统器官功能衰竭家兔肠道菌群改变的动态观察及其意义

EXPERIMENTAL STUDY ON THE CHANGES IN THE INTESTINAL FLORA IN RABBITS WITH MULTIPLE SYSTEM ORGAN FAILURE

采用家兔MSOF的实验模型,动态观察了回盲部肠道菌群的变化及其与菌血症、内毒素血症的关系。结果表明:MSOF组肠道拟杆菌数量无明显改变,而肠杆菌显著增多,与血液、脏器细菌阳性率、血浆内毒素含量等变化趋势相平行。提示:肠道菌群紊乱能促进肠源性菌血症及内毒素血症的发生与发展,在导致MSOF病理过程中具有一定的意义。

A new animal model of multiple system organ failure (MSOF) in rabbits is used in this experiment. The purpose of the current study is to observe dynamically the changes in the intestinal flora, the relationship between the changes and bacterial translocation to various organs and endotoxemia. The results show that there is no obvious alteration in population of Bacteroides, but a significant increase in enteric bacilli population in the contents of the ileocecum is found. Changes in the intestinal micro-flora correlate to the positive bacterial culture of the blood, viscera, and the level of endotoxin in the plasma. The results of our work suggest that ecological imbalance in the intestinal flora may promote-the gut-derived septic process and the development of MSOF.