生后3周至成年大鼠回肠集合淋巴小结部肠上皮的结构特征

HISTOLOGICAL FEATURES OF INTESTINAL EPITHELIUM OVERLAYING ILEAL AGGREGATED NODULES OF RAT——A LIGHT MICROSCOPIC AND ELECTRON-MICROSCOPIC OBSERVATION

本研究应用光镜与电镜技术,观察了大鼠回肠集合淋巴小结部表面肠上皮的组织学特征。成年大鼠回肠集合淋巴小结部的肠上皮,由吸收细胞、M细胞及少量的杯状细胞组成。M细胞于3周龄鼠可观察到,其胞质较多,顶端有微绒毛结构,尚未出现微皱褶,上皮内侵入的淋巴细胞较少。于4周龄鼠至成鼠,M细胞呈成熟状态,其表面形成微皱褶,细胞质较少,细胞基底面形成凹陷,覆盖着许多上皮内淋巴细胞、浆细胞及巨噬细胞。

The histological features of the intestinal epithelium overlaying the ileal aggregated lymphatic nodules of rats were observed by light and electron microscopy in this study. In adult rats, the intestinal epithelium overlaying the ileal aggregated nodules was composed of absorptive cells, microfold cells (M cells) and a few goblet cells. In 3-week old rats, M cells could be found with abundant cytoplasm and apical microvilli, but no microfold. The invading lymphocytes in epithelium were less at this time. From 4-week old till adulthood, M cells mature and with apical microfolds and scanty cytoplasm. The base of M cell formed a indentation and covered many intraepithelial lymphocytes and macrophages.