中药复方药效物质基础的研究方法与技术

Investigative Methodology and Technology for Pharmacodynamic Material Basis of Compound Prescription of Traditional Chinese Medicine

中药复方化学物质基础的研究和药效模型的建立是中药现代化的关键问题。本文利用现代高效色谱方法及其联用技术对中药全成分范畴进行系统分离和分析，并结合药理实验，以阐明起作用的主要组成或成分，进一步利用制备色谱重组，对这些组分或成分进行药效验证和配伍优化。

The key of the modernization of Traditional Chinese Medicine is to clarify chemical material basis and to found pharmacological model. This article indicates that many complex components extracted from Chinese herbal medicines are systematically separated and analyzed by high performance chromatography and coupling techniques, while their major effective constituents or components are enucleated by pharmacological experiments. Furthermore, their pharmacological data are tested and verified and their compatibleness is optimized by preparative HPLC.