顺产与剖宫产产妇血清中泌乳素水平与初乳中抗感染因子浓度的比较

Comparison of the levels of serum prolactin and the concentrations of anti-infective factors of human colostrum in normal labor and cesarean section

目的 :比较顺产与剖宫产产妇血清中泌乳素水平及初乳中抗感染因子的含量的差异。方法 :①采用放射免疫COAT -A -COUNT(包被管 )法测定顺产与剖宫产组产后 48h、96h泌乳素 (PRL)的含量。②采用免疫比浊法测定顺产与剖宫产组分娩后 48h、96h初乳中SIgA、IgG、IgM、补体C3、C4 浓度。结果 :①血清中PRL的水平 ,顺产组与剖宫产组对比 ,产后 48h有显著差异 (P <0 0 1) ,产后 96h两组无显著差异 (P >0 0 5 )。②产后 48h剖宫产组初乳中SIgA、IgG、C3、C4 浓度明显高于顺产组 (P <0 0 5或P <0 0 1) ;产后 96h剖宫产组C4 浓度明显高于顺产组 (P <0 0 5 ) ,其余无显著差异。③产后 48h剖宫产组PRL的水平低于顺产组 ,乳汁分泌少 ,而抗感染因子都明显高于顺产组。结论 :产后 48h ,产妇血清中PRL的水平顺产组高于剖宫产组 ,所以剖宫产产后泌乳始动迟于顺产组 ,乳量少且浓缩 ,初乳中抗感染因子 (SIgA、IgG、C3、C4 )的含量明显高于顺产组。剖宫产后应坚持母乳喂养 ,要注意新生儿的喂养 。

AIM: To compare the difference in serum prolactin levels and the concentrations of anti-infective factors of human colostrums between normal labor and cesarean section. METHODS: The serum prolactin levels were measured at 48 h, 96 h after parturition in 100 cases of normal labor and cesarean using radioimmunoassay. Furthermore, the levels of SIgA, IgG, IgM, C 3, C 4 were tested in 100 cases at the same time using the technique of immuno-turbidimetry. RESULTS: The serum prolactin levels in normal labor tested at 48 h after parturition were significantly different with that of the cesarean section group. But there was no significant difference in serum prolatin levels 96 h after parturition between the two groups. The levels of SIgA,IgG,IgM,C 3 and C 4 of the colostrum in the cesarean group were higher significantly than those of the normal group at 48 h after parturition. ( P< 0.05 or P< 0.01). At 96 h after parturition, there was no significant difference in SIgA, IgG, IgM and C 3 between the two groups except C 4. CONCLUSION: At 48 h after paturition, the serum prolactin levels of normal labor group are higher than that of the cesarean section group. The concentrations of anti-infective factors (SIgA, IgG, IgM, C 3 and C 4) of human colostrums at 48 h after paturition in cesarean section group are higher than those of normal labor group. [