米力农治疗充血性心力衰竭的临床研究

Clinical study of milrinone in treatment of patients with congestive heart failure

目的 :观察米力农 (m ilirinone)对充血性心力衰竭的治疗效果。方法 :米力农注射液首剂按 37.5︼g/ kg静脉注射 ;继以0 .5︼g/ (kg· min)静脉滴注 4h左右。以后静脉滴注每日 1次 ,总量为 5～ 10 m g,疗程 7d,用 Swan- Ganz球囊导管监测血流动力学效应。结果 :治疗后心脏指数由 (3.0 6± 0 .72 )增至 (4 .11± 0 .35 ) L/ (min· m2 ) ;心排出量由 (5 .77± 1.15 )增至 (7.73±0 .92 ) L/ m in,两者均显著增加 ,而平均肺毛细血管楔压、平均肺动脉压力、外周血管阻力显著下降 ,P值均 <0 .0 5 ,血压和心率改变不明显 (P>0 .0 5 )。临床症状明显改善 ,总有效率达 88.9%。结论

AIM: To investigate the effect of milrinone in the treatment of patients with congestive heart failure. METHODS: A bolus of 37 5 to 50 μg/kg milrinone injection was administered following by 0 5 μg/(kg·min) intravenous infusion for 4 h in the first day, then a total doses of 5 to 10 mg/d was given for 7 d. The hemodynamic response was monitered by Swan Ganz ballon cathate. RESULTS: The cardiac index (CI, L/(min·m) was elevated to (4 11±0 35) from (3 06±0 72) ( P <0 01); the cardiac output (CO, L/min) was elevated to (7 73±0 92) from (5 77±1 15) ( P <0 01). The value of pulmonary capillary wedeg pressure (PCWP), mean pulmonary artery pressure (mPAR), systemic vascular resistance (SVR) were significantly decreased ( P <0 05). But value of blood pressure and heart rates (HR) didn't change ( P >0 05), the clinical symptoms were significantly improved. The rate of total efficiency was 88 9%. CONCLUSION: Milrinone is a safe and effective agent in the treatment of patients with congestive heart failure.