毒扁豆碱鼻腔给药对小鼠学习记忆功能的影响

Effects of physostigmine intranasal administration on learning and memory function in mice

目的 :研究毒扁豆碱鼻腔给药对小鼠学习记忆功能的影响。方法 :采用水迷宫和被动回避性条件反应 (跳台法 ,避暗法 )试验观察毒扁豆碱鼻腔给药对小鼠学习记忆功能的影响 ,并测定鼻腔给药后血浆和脑组织内乙酰胆碱酯酶 (Ach E)的活力。结果 :毒扁豆碱鼻腔给药对东莨菪碱所致的记忆障碍有改善作用 ,并能明显降低血浆和大脑组织中 Ach E的活力。结论

AIM: To study the influence of physostigmine (Phy) intranasal administration on learning and memory function in mice. METHODS: The influence of Phy intranasal administration on learning and memory function in mice was investigated by water maze test and passive avoidance responses test (step down test and step through test), and the acetylcholin esterase (AchE) activity of the plasma and brain was measured after Phy intranasal administration. RESULTS: Phy intranasal administration improved the dysmnesia induced by scoplamine and decreased the AchE activity of the plasma and brain. CONCLUSION: Phy intranasal administraton obviously improves learning and memory function in mice.