侵袭性垂体腺瘤的相关因素分析

Relevant factors of invasive pituitary adenomas

目的 分析侵袭性垂体腺瘤的相关因素。 方法 85例垂体腺瘤患者 ,根据术中观察及瘤周围组织病理检查分为侵袭性垂体腺瘤组 (6 2例 ) ,非侵袭性垂体腺瘤组 (2 3例 )。对两组患者的临床特征、术前的影像学表现、术前术后血催乳素 (PRL)、生长素 (GH)水平的动态测定结果进行对比分析。 结果 侵袭性垂体腺瘤患者临床症状进展快 ,较多的出现颅神经功能缺失症状 ;影像学检查多显示为大腺瘤 ,颅底骨质受损率高 ,肿瘤呈多方向、不规则生长 ;MRI显示肿瘤侵袭到海绵窦的特异性指标为颈内动脉包绕。术前、术后的内分泌功能测定可以反应出功能性垂体腺瘤的肿瘤残余和复发。 结论 对患者的临床特征、影像学表现。

Objective To analyze the relevant factors of invasive pituitary adenomas. [WT5”HZ]Methods[WT5”BZ] A total of 85 patients with pituitary adenomas were divided into invasive pituitary adenomas group (62 patients, group A) and non invasive pituitary adenomas group (23 patients, group B) according to operative findings and results of pathological examination of the adjacent tissues. The clinical features, radiographic manifestations and endocrine level were determined in all the patients and compared between the two groups. [WT5”HZ]Results[WT5”BZ] Clinical symptoms advanced more rapidly and symptoms of cranial nerve functional deficiency appeared more frequently in the group A than in the group B. In the group A, the imaging finding of the tumors were more frequent with macroadenomas and the rate of damage of skull base tissue was higher. Furthermore, the tumors grew more rapidly and in more directions. The specific indication for diagnosis of tumor invading the cavernous sinus by MRI was encasement of the internal carotid artery. Preoperative and postoperative determination of endocrine functions could reflect residual tumors and the recurrence of functional pituitary adenomas. [WT5”HZ]Conclusions[WT5”BZ] The comprehensive analysis of the clinical features, imaging manifestations and endocrine functions can greatly promote the prediction of invasiveness of pituitary adenomas.