异丙酚与依托咪酯全麻诱导中对血流动力学的影响比较

A Comparison of Effects of Propfol or Etomidate on Hemodynamics durigng Induction of General Anesthesia

目的 观察异丙酚与依托咪酯全麻诱导过程中对血流动力学的影响。方法４０例ＡＳＡＩ－Ⅱ级全麻手术病人，随机分为异丙酚组（Ｐ组， ｎ＝ ２０）和依托咪酯组（Ｅ组， ｎ＝ ２０）麻醉诱导 Ｐ组异丙酚 ｌ．５－ ２ｍｇ／ｋｇ、Ｅ组依托咪酯０．３ｍｇ／ｋｇ，加用安定０．２ｍｇ／ｋｇ、芬太尼２μｇ／ｋｇ、维库溴铵０．０４－０．０６ｍｇ／ｋｇ和琥珀胆碱１．５ｍｇ／ｋｇ。分别记录诱导前后两组的ＳＢＰ、ＤＢＰ和ＨＲ的变化。结果诱导后Ｐ组ＳＢＰ、ＤＢＰ和ＨＲ均明显下降（Ｐ＜０．０５），而Ｅ组则轻度下降或下降不明显，血流动力学与诱导前相比无明显变化（Ｐ＞０．０５）。结论 异丙酚对血流动力学的影响较为严重，明显大于依托咪酯。

Objective To investigate the effects of propofol or etomidate on hemodynamics dining induction of general anesthesia. Method Forty general anesthesia patients (ASA I-Ⅱ) were rendomly divided into group P(propofol, n = 20) and group E(etomidate, n = 20). Induction of anesthesia with propofol 1. 5 -2mg /kg in group P and with etomidate 0. 3mg/kg in group E. Diazepamum 0. 2μg/kg, Fentanyl 2μg/kg,Vecuroni um 0. 04 - 0. 06 mg/kg and succinycholine 1.5mg/kg were given in two groups. The changes is SBP.DBP and HR were recorded before and after induction. Results After indution, the SBP.DBP and HR were significantly decreased in group P(P < 0.05), and less significantly decreased in group E, no significanty difference on hemedynamics before and after induction(P > 0. 05).Conclusion Effects of propofol on hemodynamics are obviously more potent than etomidate.