中剂量洛伐他汀与弹性酶治疗原发性高脂血症研究

Study of Effect of Mean - dose Lovastatin in the Treatment of Essential Hyperlipidemia

目的 研究中剂量洛伐他汀对原发性高脂血症的治疗效果。方法按照随机单盲对照法把患者分为２组，在控制饮食的基础上，治疗组 ６１例口服洛伐他汀每晚 ２０ｍｇ，对照组口服弹性酶 ６００ｍｇ， ｔｉｄ，均 ８周为 １个疗程。结果 洛伐他汀组治疗前后血脂（ｍｍｏｌ／Ｌ）水平自身对比：ＴＣ、ＴＧ、ＬＤＬ－Ｃ、ＶＬＤＬ．Ｃ分别从６．８６ ± ０．９９、２．０４±１．０４、５．１７±１．０１、０．４６±０．４２降至４．６１±０．８２、１．３１±０．６３、３．００±０．８１及０．２７±０．１３（均Ｐ＜０．００１），ＨＤＬ－Ｃ从１．１９±０．３８升至１．３２０．３９（Ｐ＜０．０５），致粥样硬化指数从４．７６降至２．４９。弹性酶组，ＴＣ（ｍｍｏｌ／Ｌ）从６．１５±０．７６降至５．７７±０．８０（Ｐ＜０．０１），ＬＤＬ－Ｃ（ｍｍｏｌ／Ｌ）从４．５４±０．７６降至４．２１±０．７８（Ｐ＜０．０５），而对ＴＧ、ＶＬＤＬ－Ｃ、ＨＤＬ－Ｃ及致粥样硬化指数无明显影响。两组调脂疗效比较：洛伐他汀降低冗、ＴＣ、ＴＧ的总有效率分别为９６．７％和７５．４％，升高ＨＤＬ－Ｃ总有效率６３．９％；而弹性酶降低ＴＣ、ＴＧ的总有效率均为３６．７％，升高ＨＤＬ－Ｃ总有?

Objective To investigate the effect of mean - dose Lovastatin in the treatment of essential hyperlipidemia. Methods 91 cases were randomly single - blindly assigned into tested(n = 61 ) and contral group (n = 30), Besides the controlling of diet, patients in the tested were beted with Lovastatin 20 mg, orally, qn;while subjects in the control group with Elastase 600mg tid, for the come of 8 weeks. Results Aner 8 weeks of treatment, compared with itself in the tested group, the levels of TC.TG.LDL - C .VLDL - C decreased from 6. 86±1 0.99(mlnol/L) to 4.61 ± 0. 82.2.04± 1 .04 to 1 .31 ± 0.63.5. 17 1±1 .01 to 3.00±0. 81.0.46 ± 0.42 to 0.27± 0. 13 respectively, all P< 0.00l; HDL- C rised from 1. 19 ± 0.38 to 1 .32 ± 0. 39, P < 0. 05; Al decreased from 4. 76 to 2. 49. There were significant differences(p < 0.001 ) between the groups. There were no obvious itfluences on functions of liver and kidney, level of blood sugar. Conclusion 20 mg/d for Lovastatin is a proper dose, the efficacy of regulating lipids is ideal and all - rounded, side effects are relatively slight.