氯己定-碘配盐消毒剂的制备及其对几种常见病原体的灭活作用

Preparation of disinfectant chlorhexidine-iodine complex and its germicidal efficiency to several pathogens

目的 :探讨氯己定 -碘配盐消毒剂简单高效的制备方法 ,并观察其对临床常见病原体的灭活作用。方法 :以氯己定和碘为原料 ,乙醇为溶剂 ,在适当条件下制备氯己定 -碘配盐 ;测定了氯己定 -碘配盐对临床常见细菌、芽胞、白色念珠菌等病原体的灭活作用 ;并与几种常用消毒剂比较它们对 3种致病细菌的灭活作用。 结果 :本制备方法的收率为 45 % (以碘计 ) ;氯己定 -碘配盐制剂 (质量浓度为 312～ 6 2 5μg/ m l)可有效灭活致病细菌、芽胞和白色念珠菌达 99.99% ;质量浓度为 1g/ L的氯己定 -碘配盐制剂对 HBs Ag阳性血清病原体灭活率也达到 99.95 % ;其对于临床 3种致病细菌的灭活作用明显优于其他消毒剂。结论 :本文报道的氯己定 -碘配盐制备方法高效、简便 ,该制剂的消毒作用明显 ,灭菌率高 。

Objective: To prepare the disinfectant chlorhexidine iodine complex with a high yield method and to observe its inhibitory effect on several pathogens.Methods: Iodine was complexed with chlorhexidine acetate under the controled conditions and the complex was produced by the process of washing, re crystallization and drying. The germicidal efficiencies to 3 kinds of bacteria were observed comparing with disinfectants in common use. Results: The complex yield was 45% by the preparation method. The solution of 312 625 μg/ml chlorhexidine idoine complex could kill bacteria, sporangia, Candida albicans up to 99.99%, and the solution of 1 g/L could kill the activity of HBsAg up to 99.95%. The germicidal efficiencies of chlorhexidine iodine complex to 3 kinds of bacteria were significantly higher than those of other disinfectants. Conclusion: This preparation method is simple and with high yield. The inhibitory effect of the disinfectant on several pathogens is significant and with high efficiency. The disinfectant is of high clinical value. [