大剂量醛氢叶酸加5-FU持续48小时滴注为主方案治疗晚期胃癌的初步研究

High Dose Holinic Acid, 5-Fluorouracil Bolus and 48 HoursContinuous Infusion in Patients with Advanced Gastric Cancer

目的:评价大剂量醛氢叶酸加5氟尿嘧啶5fluorouracil5FU持续48h滴注为主方案治晚期胃癌的客观疗效及不良反应探索晚期胃癌较合理的治疗方案。方法:对入选的31例晚期胃癌病人采用大剂量醛氢叶酸+5FU持续48h滴注为主方案进行治疗平均2.55个疗程。结果:完全缓解completeremissionCR2例部分缓解partialremissionPR14例稳定nochangeNC12例进展progressivediseasePD3例有效率为51.61%。主要的不良反应为恶心呕吐、口腔粘膜炎、骨髓抑制、脱发及腹泻。上述不良反应除恶心呕吐较明显外其余绝大多数为Ⅰ～Ⅱ度且发生率不高经常规对症治疗后见好转。结论:大剂量醛氢叶酸+5FU持续48h滴注为主方案治疗晚期胃癌疗效好不良反应轻。

Objectives: To assess the anti tumor efficacy and safety of high dose folinic acid plus 5 fluorouracil bolus and continuous infusion 48 hours in the treatment of the patients with advanced gastric cancer. Methods: Thirty one patients with advanced gastric cancer were treated with high dose folinic acid plus 5 Fluorouracil bolus and continuous infusion 48 hours. Results: There were two complete response,fourteen partial response, twelve no changes and three progressive disease in this series with total response rate of 51.61%. The main side effects include nausea and vomiting, mucositis, bone marrow suppression, alopecia, and diarrhea. Other side effects were uncommon. All side effects were tolerable and mild except nausea vomiting. Conclusions: High dose folinic acid plus 5 Fluorouracil bolus and continuous infusion 48 hours may be a safe and effective therapy for the patients with advanced gastric cancer.