肺癌合并上腔静脉综合征138例临床分析

Clinical analysis on 138 cases of lung cancer complicated with superior vena cava syndrome

目的:对肺癌合并上腔静脉综合征治疗方式进行回顾性分析,以探讨最佳治疗途径。方法:将138例患者分为单纯放疗组42例:单纯化疗组48例,综合治疗组（化疗+放疗+化疗）48例,进行疗效比较分析。结果;缓解率（CR+PR）综合治疗组为87.5％,明显高于单纯放疗组的52.4％（P<0.05）,亦高于单纯化疗组的54.2％,（P<0.05）,其平均缓解时间及生存期亦优于单纯放、化组。结论:肺癌合并上腔静脉综合征的治疗,应先给予1～2周期的冲击化疗,继之放疗,以提高局部控制率,最后根据病情给予周期不等的化疗较为有效。

Objective:To evaluate the best treatment method by retrospective analysis on therapy for 138 cases of lung cancer complicated with superior vena cava syndrome. Methods: 138 patients were divided into three groups:radiotherapy alone group (42 cases), chemotherapy alone group (48 cases) and combined therapy group (48 cases) . Results: In combined therapy group, an overall response rate of 87.5% was significantly higher than that of 52.4% and 54.2% in radiotherapy alone and chemotherapy alone group, respectively (P<0.05) with longer average remission stage and survival time.Conclusion: In the treatment for lung cancer complicated with superior vena cava syndrome, one to two cycles of stosstherapy should be first given, and then radiotherapy was performed to raise local containment rate and last different cycles of chemotherapy were administered according to patients condition.