白介素-2对恶性血液病化疗患者免疫功能的影响

Effect of Interleukin-2 on Immunity Function of Patients with Malignant Hematologic Disease under Chemotherapy

目的 :探讨白介素_2 (IL_2 )对恶性血液病化疗患者免疫功能的影响。方法 :75例恶性血液病患者分化疗加IL_2组 (实验组 40例 )和单纯化疗组 (对照组 35例 )。实验组于化疗的同时用IL_2 40IU/m2 /d ,连续 5～ 7天 ,间歇 2周后重复用IL_2 ,两个疗程后检测T细胞亚群和免疫球蛋白的变化。结果 :实验组化疗后CD3 、CD4 、CD4 /CD8比值及免疫球蛋白IgG、IgM明显高于本组化疗前和对照组化疗后的水平。结论 :IL_2可提高恶性血液病化疗患者的免疫功能。

Objective:To observe the effect of interleukin_2 on immunity function of patients with malignant hematologic disease under chemotherapy.Methods:Seventy_five cases were divided into experimental group(the patients were given chemotherapy and IL_2,IL_2 40IU/m 2/d,iv,for 5～7days)and control group(the patients were given chemotherapy).The changes of T_cell subpopulation of their peripheral blood and plasma immunoglobulin were monitored after two periods of IL_2 treatment.Results:The positive percentage of CD 3、CD 4,CD 4/CD 8 ratio and IgG、IgM after chemotherapy in experimental group were significantly higher than those before chemotherapy in the same group and those after chemothe_rapy in control group.Conclusion:IL_2 can increase immunity function of patients with malignant hematologic disease under chemotherapy.