一次新生儿轮状病毒性腹泻的流行病学分析

An outbreak of neonatal diarrhea caused by rotavirus

目的 调 研1994年4月本院婴儿室发生的一次新生儿肠炎流行的流行规律及发病病原。方法 用10%聚丙烯酰胺凝胶电泳（PAGE）及酶联免疫吸附试验检测患儿粪便中轮状病毒。结果 共查出阳性标本 23份,阳性率为45.3%。其平均发病日龄为（4.0±1.8） d，经治疗全部患儿均痊愈出院，平均病程为（9.1±4.0） d。结论 本次流行为轮状病毒感染，对传染源的管理是控制疾病流行的关键所在。

： Objective To investigate the epidemic pattern of an outbreak of neonatal diarrhea occurred in neonatal unit of our hospital and identify the etiological agent of the diarrhea outbreak. Methods In 322 babies born within a period of 24 d, 86 (26.7%) presented various diarrheal symptoms. Stool specimens were collected and examined with polyacrylamide gel electrophoresis and enzyme link immunoadsorption assay. Results Identical rotavirus dsRNA were detected in 23(45.3%)out of 53 specimens from the babies with diarrhea and the average incubation period was estimated at 4.0±1.8 d. All patients were discharged with full recovery after treatment with a mean course of 9.1±4.0 d. Conclusion The investigation suggests that this outbreak of neonatal diarrhea was caused by rotavirus infection.