泰胃美用于围麻醉期呕吐误吸的防治(附30例分析)

Effect of Tagamet on Prevent of Vomiting and Mistaking Aspiration during Perianesthetic Period(with Analysis of 30 Cases)

目的 通过测定静脉注射泰胃美前后胃液 p H及血清胃泌素含量 ,探讨泰胃美对围麻醉期呕吐、误吸的防治作用。方法 选择胆囊切除手术 30例 ,随机分成实验组和对照组各 15例 ,实验组于全麻诱导前 30分钟静脉注射泰胃美 2 0 0 mg,对照组静脉注射生理盐水 2 ml。全部病人采用气静 +吸入复合麻醉 ,分别于麻醉诱导前、后 30分钟 ,抽取静脉血 2 .0 ml测定胃泌素含量及吸取胃液 5 .0 ml测定 p H值。结果 应用泰胃美前胃液 p H值为 2 .8± 0 .5 ,而用泰胃美后 30分钟胃液 p H上升为 4.5± 0 .6 (P<0 .0 1)。应用泰胃美前血清胃泌素含量为 138.5 6± 5 6 .38(pg/ ml) ,而用泰胃美 30分钟后为 111.6 0± 45 .6 (P<0 .0 1)。结论 应用泰胃美可使胃酸和胃泌素分泌下降 ,胃液 p H值迅速增高 ,可达 4.0以上。对预防呕吐、误吸及误吸性肺炎。

Objective:To investigate results of the treatment of Tagamet for vomiting and mistaking aspiration during perianesthtic period.Methods:30 patients with cholecystectomy were divided into two groups at random.Intravenous Tagamet was used before general anesthesia in the experimental group.Serum gastrin and pH of gastric fluid were tested before and after general anethesia.Results:pH of gastric fluid was 2 8±0 5 before using Tagamet and 4 5±0 6 after using Tagamet(P<0 01).Serum gastrin was 138 56±56 38 before using Tagamet and 11 60±45 6 after using Tagamet(P<0 01).Conclusions:Tagamet reduces gastric acid secretion and level of gastrin.It is the certain significance to prevent vomiting,mistaking aspiration,aspiration pneumonia and breath failure.