乙肝携带者C_3/Ig双特异性免疫复合物与体液免疫的相关性研究

Correlation of C_3/Ig Two-Component-Determined Circulating Immune Complexes with Humoral Immunity in HBsAg Asymptomatic Carriers

目的 研究 HBs Ag无症状携带者 (ASC)的体液免疫反应。方法 采用直线相关分析法 ,较系统地研究ASC的 C3/ Ig双特异性循环免疫复合物 (C3/ Ig M- TCIC、C3/ Ig G- TCIC和 C3/ Ig A- TCIC)与 Ig M、Ig G、Ig A和 C3的相关性。结果 在健康对照组的诸种具有相关关系的指标中 ,ASC仅在 C3/ Ig M- TCIC与总和游离 Ig M以及 C3/ Ig G- TCIC与总和游离 Ig A具正相关与之一致。此外 ,ASC的 C3/ Ig G- TCIC与复合 Ig A呈显著负相关 ,而健康人与之无关。结论 ASC确存在体液免疫调节紊乱。其中最主要的是具有重要中和作用的 Ig

Objective:To study humoral response in HBsAg asymptomatic carries(ASC).Methods:Association of C 3/Ig two component determined circulating immune complexes(C 3/Ig TCIC:C 3/IgM TCIC,C 3/IgG TCIC and C 3/IgA TCIC)with IgM,IgG,IgA and C 3 has been characterized by correlation analysis.Results:Compared with correlation markers from the healthy controls,only positive correlation of C 3/IgM TCIC with total and free IgM and C 3/IgG TCIC with total and free IgA occurred in ASC.Conclusion:There is indeed a regulation disorder of humoral immune in ASC,in which low neutralizing antibody of IgG class is a main problem.